In October of last year I had the honour of speaking at CFinNC, a ColdFusion / Flex / AIR conference organized by the Triangle Area ColdFusion User's Group. It was an outstanding conference; well run, with informative sessions on timely topics, which is pretty amazing considering that it was absolutely free.
Registration is already open, as is a Call For Presentations. I'm hoping to get a chance to speak again this year, but even if I don't I'll be there to partake in the learning and festivities. If it turns out to be anywhere near as good as CFinNC (and I'm sure it will), it will be a conference that you won't want to miss.